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Table 3 Predictors of early hyperlactatemia with univariate and multivariable logistic regressiona

From: The effect of hyperlactatemia timing on the outcomes after cardiac surgery

Univariable

Multivariable

Variable

β

SE

OR

CI

P

β

SE

OR

CI

P

DM

− 0.94

0.33

0.39

0.20–0.75

0.005

− 1.3

0.4

0.26

0.12–0.55

< 0.001

Glucose

0.11

0.05

1.11

1.01–1.2

0.03

0.18

0.06

1.3

1.1–1.3

0.003

CPB time

0.09

0.03

1.1

1.03–1.14

0.001

0.07

0.03

1.02

1.01–1.1

0.015

Clamp time

0.10

0.03

1.1

1.04–1.17

0.001

     

Procedurea

    

0.07

     

 Valve(s)

0.42

0.38

1.5

0.75–3.2

0.24

     

 Combinedb

1.2

0.48

3.4

1.3–8.7

0.01

     

 Other

0.75

0.65

2.1

0.60–7.5

0.24

     
  1. CPB indicates cardiopulmonary bypass time (min) and the variables are analyzed at 10 min increment. Clamp time is also analyzed at 10 min increment. DM indicates diabetes mellitus. Glucose is analyzed at 1 mmol/L increment. Variance inflation factor (VIF) for all variables included in the multivariable model is < 4. Cross-clamp time and cardiopulmonary bypass (CPB) times were highly correlated and induced collinearity into the multivariable model (VIF = 5 for both variables when both are included in the model). Therefore, the cross-clamp time variable was removed from the multivariable model. Variables with P value > 0.2 on univariate analysis are not included in the table. Variables included in the multivariable model are variables that had a P value < 0.2 on univariate analysis and had no collinearity and these include (DM, glucose level, CPB time, and procedure) using the backward elimination method. Logistic regression multivariable model Hosmer and Lemeshow P value = 0.7. Area under the receiver operating characteristic (ROC) curve for the multivariable model is 0.71, P < 0.001. Bonferroni correction for P value adjustment was employed based on the number of explanatory variables tested with the univariate logistic regression model
  2. aThe reference group for surgical procedure variable is isolated coronary artery bypass grafting (CABG)
  3. bCombined indicates combined CABG and valve(s) procedures