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Transcatheter versus surgical closure of ventricular septal defect: a comparative study



In many countries, surgical closure of ventricular septal defects remains the recommended approach of ventricular septal defect closure. The aim of this study is to compare the safety, efficacy, and clinical effects of surgical versus transcatheter closure of a ventricular septal defect.


We conducted a comparative randomized study on patients undergoing ventricular septal defect closure. Patients were allocated to undergo either surgical (group I) or catheter (group II) ventricular septal defect closure.


Seventy-two patients were included. Operation success was achieved in 100% of the surgical group versus 33 of 36 patients of the percutaneous group (91.6%) (p value 0.076). There was no significant difference regarding the residual ventricular septal defect. The postoperative echo in group I revealed severe tricuspid regurgitation in one patient (2.7%), and one patient needed a permanent pacemaker. On the other hand, in group II, during the procedure, one patient had severe tricuspid regurge (2.7%). There was a significant difference in the postoperative data favoring group II over group I regarding ventilation duration, intensive care unit stay, total hospital stay, and blood transfusion (P value < 0.001 each).


Both transcatheter device closure and surgical repair are effective treatments. In contrast, the psychological profile of the transcatheter device was superior to the surgical repair, especially in terms of avoiding sternotomy scar, blood loss and transfusion, and hospital stay. On the other hand, transcatheter intervention is limited only to the anatomically suitable ventricular septal defects, in addition, surgical backup is a must in case of complicated transcatheter closure, which gives the upper hand to surgery to be the recommended approach for most of the ventricular septal defects.

Clinical registration number

NCT05306483 registered 04/05/2022 (retrospectively registered) at PRS.

Graphical Abstract


Children with ventricular septal defect (VSD) account for 20% of all Congenital heart diseases (CHDs) [1]. The most prevalent hemodynamically significant subtype is a perimembranous ventricular septal defect (pmVSD) [2]. Before catheter-based closure was available, the gold standard therapy for VSD closure was surgery [3]. However, surgical closure has several consequences, including scars from the incision, infection, and postoperative pain [4].

In 1994, Rigby and Redington used the Rashkind double umbrella device to demonstrate transcatheter closure of the VSD [5]. Hijazi et al. were the first to employ the Amplatzer VSD occluder device to close the VSD in 2002 [6], which became extensively used in numerous centers around the world due to its minimally invasive design [7]. Device-related consequences include complete heart block (CHB), tricuspid and aortic regurgitation, and device embolization limiting its usage [8]. However, recent improvements in device design and operator skills have dramatically improved the results of employing the transcatheter method to treat VSDs [9]. The bundle of His and its branches are strongly connected to the infero-posterior border of VSD. Consequently, its closure has been linked to an increased risk of CHB. Even in individuals with atrioventricular septal malalignment, surgeons now know where the conduction tissue is located and can avoid damaging it [10]. The possible risk of catheter closure was therefore identified as the occurrence of an iatrogenic CHB. As a result, in many countries, surgical closure of VSDs remains the recommended approach of VSD closure [9]. The aim of this study is to compare the safety, efficacy, and clinical effects of surgical vs. transcatheter closure of VSDs.


Setting and ethical considerations

The present study was conducted at Ain Shams University Hospitals. The study protocol was approved and registered by the local ethics committee of Ain Shams Faculty of Medicine (FMASUMS 97/2021) and registered at (NCT05306483 registered on 04/05/2022). The study was conducted in accordance with the declaration of Helsinki. All methods were performed in accordance with the relevant guidelines and regulations. The legal guardians of each patient gave an informed consent before and after randomization and submission to the procedure.

Study design and patients

We conducted a comparative randomized, prospective study that recruited patients scheduled to undergo closure of VSDs at our institutions through the period from March 2021 to March 2022. The study included 72 VSD patients suitable for both surgical and transcatheter closures according to guidelines [11]. Peri-membranous defects > 4 mm away from the aortic valve and muscular defects were considered suitable for catheter closure. Only patients with New York Heart Association (NYHA) class I–III and a weight of at least 8 kg were included. We also included patients with left-to-right shunt and Qp/Qs > 1.5. We excluded patients with other congenital cardiac or valvular abnormalities who are indicated for surgical intervention of their valvular disease, infective endocarditis, atrioventricular block, atrial or supraventricular arrhythmia, history of stroke, systemic thromboembolism, rheumatic heart disease, and/or Cushing syndrome.

Sample size calculation

Considering the very close documented operative success and major complications rate of the two interventions, we used the hospital stay duration as an indicator for the calculation of the sample size. Considering the study of Zheng et al. [12] as a reference, the sample size was calculated as a study power of 80.0% and α probability error of 5.0%. Sample size calculation was achieved using G Power (Kiel University, Germany).

Preprocedural assessment

Patients were assessed preoperatively for sociodemographic characteristics, anthropometric measures, and consanguinity. All patients underwent transthoracic echocardiographic (TTE) examination, including two-dimensional and color-flow Doppler techniques.

Randomization and blinding

Before randomization, the study objectives, selection criteria and technique, and possible risks of the study interventions were plausibly explained to the legal guardians of included patients. Before the last preoperative visit, all patients were randomized to either of the study interventions using computer-generated random tables and the sealed envelope technique. All patients were considered as one group without randomization blocks classified according to clinical or echocardiographic data (simple randomization). Randomization process was supervised by an independent researcher who wasn’t aware of the study objectives. In the last preoperative visit, all patients and/or their legal guardians were informed about the type of intervention to which they were allocated. All of them agreed to the allocated intervention and provided written informed consent.

Transcatheter device implantation

VSD occluder is an expandable device. The closure was done under general anesthesia after the patients were fully heparinized (100 IU/kg). The TEE was performed intraoperatively to assess the defect during device positioning. A left ventriculogram in the left anterior oblique projection was acquired to profile the VSD. A Terumo wire was used to cross the VSD with a right Judkins catheter. The guidewire was snared from the pulmonary artery or vena cava to create an arteriovenous circuit. A long sheath (6–9 Fr) was advanced to the left ventricle. A left ventriculogram and TEE data were used to choose an occluder. The occluder was placed via the long sheath under fluoroscopic and echocardiographic guidance. Following the intervention, all patients were moved to post-Cath care unit. The ECG was continually monitored for the first 24 h. Patients who had no issues were regularly hospitalized for 24 h only. Patients with arrhythmias such as extended PR interval or atrioventricular block were hospitalized for follow-up till improvement. All patients received daily aspirin (5 mg/kg) following the procedure.

Surgical procedure

The surgical closure was performed under general anesthesia via hypothermic cardiopulmonary bypass and cardioplegic arrest. The chest was opened using the conventional median sternotomy technique. Surgical techniques were determined by the nature of each defect and include direct closure and patch closure with autologous pericardium; however, polyethylene terephthalate (Dacron; C.R. Bard, Haverhill, MA) and expanded polytetrafluoroethylene (Gore-Tex; W.L. Gore & Associates, Inc., Phoenix, AZ) may be used on occasion. Sutures were used to secure these patches in place. Direct closure (without a patch) may be used for minor faults. The majority of VSDs were corrected with right atriotomy to avoid the disadvantages of the Trans ventricular method.

Follow-up and study outcomes

The patients were followed up till they have been discharged from the hospital. The primary outcome of the present study was the rate of residual VSD shunts as detected by the 2D-TTE. The secondary endpoints include the need for blood transfusion, length of hospital and ICU stay, complications, and especially complete heart block.

Safety monitoring

There are no safety concerns as both procedures are well established. However, an interim analysis was carried out every 3 months after the initial follow-up period.

Statistical analysis

All statistical analyses were performed using SPSS version 22.0 for Windows. Continuous data were expressed as mean (± standard deviation [SD]), and categorical data were described as percentages. The association between type of closure and perioperative characteristics was tested using the Chi-square test or Independent t-test, with a p-value < 0.05 donating statistical significance.


Seventy-two patients were included according to the calculated sample size There was no significant difference in the demographic data between group I and group II regarding age, weight, height, and BSA (P-value 0.1; Table 1).

Table 1 Comparison between group I and group II regarding preoperative data

Concerning the preoperative echocardiogram data, the group I showed overall, 29 (80.6%) of VSDs were perimembranous, and seven (19.4%) were muscular. The mean size of VSDs was 7.36 ± 2.80 mm. In group II, the preoperative ECHO showed that 23 (63.88%) of VSDs were perimembranous, and 13 (36.11%) were muscular. The mean size of VSDs was 5.39 ± 1.36 mm. There was no significant difference in the preoperative echocardiogram data between group I and group II regarding LVEDD, LVESD, IVS, LA, size of VSD (P-value 0.43), and RV (P-value = 0.33) (Table 1).

In group I, direct closure of VSD was done in one patient (2.7%). The pericardial patch was used in five patients (13.8%) while a Gortex patch was used in most of the patients (83.3%) (Fig. 1).

Fig. 1
figure 1

Methods of VSD closure in group I

In group II, the mean disc diameter was 10.33 ± 2.53 mm. The total fluoroscopic time was 14.83 ± 11.67 min (Table 2).

Table 2 Procedure data in group II

Regarding intraoperative complications of the 2 groups, in the surgical group, there was one case of CHB that needed temporary PM, follow-up of the patient with continuous monitoring and frequent all lead off -PM ECG at the intermediate ICU till restoring sinus rhythm after 3 days, while in the transcatheter group, there were 3 cases of failure as discussed below (Table 3).

Table 3 Comparison of intra-procedure complications between groups I and II

Procedure success

Surgical closure was attempted in 36 patients with a success rate of 100% as the operation was considered to be successful if there was no death and no large residual shunt. While in the percutaneous group, the success rate was 91.7% as there were 3 cases of failure of devices deployment (8.3%). Right anatomical assessment of the VSD is one of the most important factors that could predict the success of the transcatheter intervention. The cause of failure in the 1st patient was due to device instability mostly due to size-device mismatch. Although there were multiple trials of assessment of the anatomy and the size of the defect, the device instability occurred which should introduce the way to another additional imaging method of assessment that may eliminate this risk.

The operation was canceled and the patient has been referred to elective surgery. The second patient developed severe TR after implantation of the device due to mechanical distortion of the tricuspid valve, the device has been removed, and the patient was referred to elective surgery as he did not show any instability in the hemodynamics. The 3rd one failed due to rhythm changing into a complete heart block while introducing the sheath as the defect was too small (5 mm). The procedure was canceled, and the patient was referred to elective surgery.

Residual shunt

It was classified into 2 degrees: small if was less than 2 mm and large if more than 2 mm. In both groups, there were no significant residual shunts as in the surgical group (group I) small residual VSD was found in five patients of 36 successful patients (13.8%), while in group II, small residual VSD in 5 patients out of 33 successful patients (15.1%).

The postoperative echo in group I revealed mild tricuspid regurge in three patients (8.3%), moderate tricuspid regurge in one patient (2.7%), and severe tricuspid regurge in one patient (2.7%). On the other hand, the postoperative echo in group II revealed: mild tricuspid regurge in 4 patient (11.1%), moderate tricuspid regurge in one patient (2.7%), and severe tricuspid regurge in 1 patient (2.7%). No cases of both groups were detected with AR.

There was no significant difference in postoperative echo between both groups regarding tricuspid regurge P value 0.641 (Table 4).

Table 4 Comparison of postoperative echocardiogram findings between groups I & II

Other complications were classified to major and minor. Major complications are late death due to a cause in direct relation to the procedure, thromboembolic events, repeating the operation, new onset severe valvular regurgitation that requires surgical intervention, device detachment, and the need for a permanent pacemaker. While minor complications are wound complications that required hospital admission or surgical debridement, reopening due to bleeding in the surgical group, groin hematoma in the transcatheter group, new arrhythmia, peripheral ischemia that not required endovascular intervention, increased one or two degrees of valvular regurge that not required intervention, self-limited hemolysis due to small residual, any effusion that required drainage as with chest tube or aspiration.

Major complications

In terms of major complications, there were no recorded cases of death during the period of follow-up; in the percutaneous group, there is one case of acute severe TR that was noticed during the advancement of the device as mentioned before. One patient in each group developed severe TR in the post-procedural ECHO, the two patients were known to have moderate TR before intervention. Accordingly, follow up with medical treatment as there was no clinical indication for surgical intervention at the time of follow-up.

Regarding the need for a permanent pacemaker, there were 2 cases of group II that developed complete heart block after being transferred to the ward, one of them restored normal sinus rhythm after 5 days, and a permanent pacemaker was inserted 2 weeks after transcatheter intervention in the 2nd patient. While in the surgical group, just one patient needed a permanent pacemaker after a complete heart block. No other major complications were recorded in both groups.

Minor complications

In group II, two patients (5.5%) had femoral hematoma after removing the femoral sheath, follow-up at the outpatient clinic occurred and no further intervention was needed.

ECG changes were recorded in 12 patients (33.3%) of the surgical group versus 10 patients (27.7%) of the transcatheter group. One patient in the transcatheter group had peripheral lower limb ischemia (2.7%) and presented with mild color changes in his right toe that resolved with medical treatment after 2 days with no intervention needed after follow-up. Two cases of the surgical group (5.55%) had significant bleeding that required surgical exploration. No significant difference between the two groups concerning minor complications.

Most of the patients in group I received blood products. In group II, All patients did not bleed nor receive blood products. There was a significant difference in the postoperative data favoring group II over group I regarding ventilation duration, ICU stays, total hospital stay, blood transfusion (P-value < 0.001 each), and ECG changes (P-value = 0.005) (Table 5).

Table 5 Comparison of Postoperative data between groups I and II

Laboratory data

Serum levels of liver enzymes, BUN, and creatinine measured before the intervention, after 1 h of transcatheter intervention and 1 h after declamping the aorta in surgical closure and every 6 h for the next 72 h (P < 0.01) (Fig. 2).

Fig. 2
figure 2

Laboratory data for the 2 groups within 48 h of the closure. AST, aspartate transaminase; ALT, alanine transaminase; BUN, blood urea nitrogen

Cardiac enzymes (CK-MB and troponin I) were normal in the two groups before the intervention; after the intervention, there was a significant difference between both groups (Fig. 3).

Fig. 3
figure 3

A cardiac kinase-MB levels during 3 days of follow-up. B Troponin I levels during 2 days of follow-up. CK-MB, cardiac kinase-MB; cTnI, cardiac troponin I


The VSD is preferred to be managed surgically in children especially in patients with a low birth weight with a large-sized defect. However, surgical closure has major limitations, including a prolonged hospital stay and increased blood transfusions. In the last several years, transcatheter VSD closure has gained a lot of interest. The lower incidence of complications, a shorter hospital stay, almost no blood transfusion, less trauma, and rapid recovery are among the benefits of this intervention [13].

Our findings were in line with those of Yang et al. [14], who conducted a randomized controlled trial to evaluate the difference between surgical and transcatheter closure in children with VSD. Their findings showed that both groups are comparable in terms of major adverse events and mortality. On the other hand, no cases in the transcatheter group required blood transfusion compared to 23 cases in the surgical group (p < 0.001).

A meta-analysis of five studies [15,16,17,18,19] demonstrated that the success rate was very high in both groups (surgery and transcatheter), with no significant difference (98.4% vs. 98.1), respectively [11]. Catheter closure resulted in a significantly lower residual shunt (RR = 0.44, p = 0.01) than surgical closure. Comparisons between the catheter and surgical methods showed that transfusions and hospital stays were dramatically reduced in the catheter group (RR = 0.02, p < 0.00001) and (RR = 4.81, p = 0.001), respectively. However, the overall consequences, complete atrioventricular block, and the cost of both techniques were comparable [10].

For surgery, the most common complications were myocardial dysfunction, severe hemorrhage, subaortic stenosis, aneurysm formation, complete heart block, and severe pulmonary hypertension [20,21,22,23,24,25,26].

Surgeons have a good understanding of how to diagnose and treat patients with a single large VSD [27].

The transcatheter repair of VSDs was shown to be easier and to have fewer complications. But For the aneurysmal form of transcatheter VSD closure, many technical challenges were critical. In the first place, successfully crossing the VSD was the most difficult step in transcatheter closure for aneurysmal VSD [28]. Using alternative catheters (e.g., partially cut pigtail catheters, 3DRC, or right Judkins) and wires may be useful in certain situations. It was also critical that the occluder be placed within the aneurysmal sac at all times in order to minimize cardiac rhythm disturbances and consequences in the case of an aneurysmal form of VSD [14].

Operator skill, VSD morphology, and VSD size all have a role in the effectiveness of transcatheter VSD closure. In this study, the size of VSD was 5.39 ± 1.36 mm in the group treated with transcatheter and 7.36 ± 2.80 mm in the surgery group. Approximately, 80% of the VSDs in the surgical group were pmVSD, and it was 63.9% in the transcatheter group. Catheter closure of large pmVSDs is more challenging. In El-Kadeem et al.'s meta-analysis, the majority of trials revealed similar VSD sizes; however, two studies indicated considerably lower VSD sizes in the catheter group than in the surgical group. In our study, the mean age of patients treated with transcatheter closure was insignificantly higher than the surgical group. The transcatheter group of pediatric patients was substantially older than the surgical group in the trials of Xunmin et al., Oses et al., and Chen et al. [16, 17, 19]. Transcatheter closure has a high success rate because of these factors.


In conclusion, the current study suggests that both transcatheter device closure and surgical repair are effective treatments, with excellent short-term outcomes. Transcatheter closure is an alternative method to surgery for the anatomically suitable VSDs in children in this study.


The small sample size of this study may hinder the generalizability of our findings. Another limitation is the lack of long-term follow-up outcomes. In addition, we did not evaluate the predictors of success in both groups.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.


AR :

Aortic regurgitation|


Alanine transaminase


Aspartate transaminase


Body surface area


Blood urea nitrogen


Complete heart block


Congenital heart diseases


Creatinine kinase-MB




Ejection fraction


Intensive care unit


Inter-ventricular septum


Ventricular septal defect


Left atrium


Left ventricular end-diastolic diameter


Left ventricular end-systolic diameter


Mitral regurgitation


Pulmonary artery systolic pressure




Perimembranous ventricular septal defect


Trans-esophageal echo


Tricuspid regurgitation


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All methods were performed according to the standard guidelines.

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HS (data curation; formal analysis; investigation; methodology; supervision; validation; writing – review and editing). MKE MBBCh (conceptualization; data curation; formal analysis; methodology; project administration; writing – original draft). AST (data curation; formal analysis; methodology; supervision; validation; writing – review and editing). YA (data curation; formal analysis; methodology; supervision; validation; writing – review and editing). AME (data curation; formal analysis; methodology; writing – review and editing). MAG (data curation; formal analysis; investigation; methodology; supervision; validation). The authors read and approved the final manuscript.

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Correspondence to Mohamed Khairat Elshahat.

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The study’s protocol was approved and registered by the local ethics committee of our institution Ain Shams University, faculty of medicine (FMASU M S 97/2021) and registered at PRS (NCT05306483 registered 04/05/2022). The study was conducted in accordance with the declaration of Helsinki. The legal guardians of each patient gave an informed consent before submission to the procedure.

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Singab, H., Elshahat, M.K., Taha, A.S. et al. Transcatheter versus surgical closure of ventricular septal defect: a comparative study. Cardiothorac Surg 31, 8 (2023).

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